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G David Roodman Selected Research

TEI 9647

4/2005(23S)-25-Dehydro-1{alpha}-hydroxyvitamin D3-26,23-lactone, a vitamin D receptor antagonist that inhibits osteoclast formation and bone resorption in bone marrow cultures from patients with Paget's disease.
5/2004Vitamin D antagonist, TEI-9647, inhibits osteoclast formation induced by 1alpha,25-dihydroxyvitamin D3 from pagetic bone marrow cells.

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G David Roodman Research Topics

Disease

38Multiple Myeloma
02/2022 - 05/2003
24Neoplasms (Cancer)
10/2021 - 01/2002
16Bone Diseases (Bone Disease)
01/2018 - 01/2002
14Bone Resorption
04/2019 - 03/2004
11Neoplasm Metastasis (Metastasis)
01/2018 - 03/2005
5Pain (Aches)
02/2021 - 06/2013
4Osteoporosis
01/2014 - 10/2007
4Prostatic Neoplasms (Prostate Cancer)
02/2012 - 04/2007
3Hypersensitivity (Allergy)
02/2021 - 06/2013
3Breast Neoplasms (Breast Cancer)
02/2021 - 10/2009
3Osteonecrosis (Kienbock's Disease)
01/2018 - 10/2006
3Spontaneous Fractures (Pathological Fracture)
01/2018 - 06/2013
3Spinal Cord Compression
01/2018 - 06/2013
2Metabolic Bone Diseases (Osteopenia)
10/2018 - 10/2009
2Compression Fractures (Compression Fracture)
10/2018 - 06/2013
2Febrile Neutropenia
01/2018 - 05/2011
2Neutropenia
01/2018 - 01/2010
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
11/2014 - 05/2011
2Lymphoma (Lymphomas)
11/2014 - 05/2011
2Osteitis Deformans (Paget's Disease of Bone)
06/2014 - 01/2014
2Osteolysis
10/2013 - 11/2002
2Rheumatoid Arthritis
01/2011 - 02/2007
2Leukemia
06/2008 - 05/2004
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
10/2007 - 03/2007
1Hypoxia (Hypoxemia)
10/2020
1Residual Neoplasm
10/2020
1Hyperostosis corticalis deformans juvenilis
01/2020
1Congenital Abnormalities (Deformity)
01/2020
1Thrombocytopenia (Thrombopenia)
01/2018
1Pneumonia (Pneumonitis)
01/2018
1Heart Arrest (Cardiac Arrest)
01/2018
1Lung Neoplasms (Lung Cancer)
11/2015
1Camurati-Engelmann Syndrome (Progressive Diaphyseal Dysplasia)
11/2015
1Waldenstrom Macroglobulinemia (Macroglobulinemia)
11/2014

Drug/Important Bio-Agent (IBA)

8Proteins (Proteins, Gene)FDA Link
01/2020 - 11/2006
8Diphosphonates (Bisphosphonates)IBA
06/2017 - 11/2002
6Pharmaceutical PreparationsIBA
02/2022 - 01/2002
5Bortezomib (Velcade)FDA Link
10/2018 - 11/2002
5LigandsIBA
12/2015 - 11/2002
5CytokinesIBA
12/2014 - 11/2002
5Interleukin-6 (Interleukin 6)IBA
06/2014 - 01/2004
5Interleukin-3 (Interleukin 3)IBA
04/2014 - 03/2004
5RANK LigandIBA
02/2008 - 03/2004
4Transcription Factors (Transcription Factor)IBA
01/2014 - 11/2002
4Chemokine CCL3IBA
10/2006 - 05/2003
3Zoledronic Acid (Zometa)FDA Link
10/2018 - 02/2014
3DenosumabFDA Link
01/2018 - 10/2006
3Annexin A2 (Annexin II)IBA
02/2012 - 07/2005
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2011 - 12/2006
3Immunomodulating AgentsIBA
01/2010 - 11/2002
3ChemokinesIBA
10/2006 - 11/2002
2Conditioned Culture MediaIBA
10/2020 - 04/2007
2Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
10/2020 - 06/2006
2Alkaline PhosphataseIBA
01/2020 - 01/2011
2Pamidronate (Aredia)FDA LinkGeneric
10/2018 - 02/2014
2Monoclonal AntibodiesIBA
01/2018 - 10/2006
2Hormones (Hormone)IBA
06/2017 - 11/2010
2alvocidib (flavopiridol)IBA
11/2014 - 05/2011
2activin AIBA
04/2014 - 02/2014
2Vitamin DFDA LinkGeneric
06/2013 - 04/2005
2Lenalidomide (CC 5013)FDA Link
05/2012 - 01/2010
2Dexamethasone (Maxidex)FDA LinkGeneric
05/2012 - 12/2006
2Integrin beta3 (GPIIIa)IBA
07/2010 - 10/2006
2NF-kappa B (NF-kB)IBA
05/2009 - 03/2007
2Calcitriol Receptors (Calcitriol Receptor)IBA
06/2008 - 04/2005
2Biological ProductsIBA
12/2007 - 03/2005
2SDX 308IBA
10/2007 - 03/2007
2Interleukin-8 (Interleukin 8)IBA
04/2007 - 10/2006
21,25-dihydroxyvitamin DIBA
12/2006 - 05/2004
2Thalidomide (Thalomid)FDA Link
12/2006 - 11/2002
2Chemokine ReceptorsIBA
10/2006 - 03/2005
2TEI 9647IBA
04/2005 - 05/2004
2Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA
03/2004 - 11/2002
1Amyloid Precursor Protein Secretases (beta-Secretase)IBA
10/2021
1HMGB1 Protein (HMG1)IBA
02/2021
15-bromo-2'-chloro-2-aminobenzophenoneIBA
02/2021
1Chimeric Antigen ReceptorsIBA
10/2020
1trans-crotonin (CTN)IBA
10/2020
1Alendronate (Alendronate Sodium)FDA LinkGeneric
01/2020
1Sp7 Transcription FactorIBA
01/2020
1plitidepsin (aplidine)IBA
04/2019
1ParaproteinsIBA
01/2018
1Aromatase InhibitorsIBA
06/2017
1ChromatinIBA
01/2017
1Histones (Histone)IBA
01/2017
1Adenosine Triphosphatases (ATPase)IBA
01/2017
1Notch ReceptorsIBA
03/2016
1Transforming Growth Factors (Transforming Growth Factor)IBA
11/2015
1CalciumIBA
11/2015
1NADPH Oxidase 4IBA
11/2015
1Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA
11/2015
1ACE-011IBA
02/2014
1romosozumabIBA
02/2014
1Clodronic Acid (Clodronate)IBA
02/2014

Therapy/Procedure

17Therapeutics
10/2020 - 01/2002
4Radiotherapy
01/2018 - 01/2008
3Drug Therapy (Chemotherapy)
12/2010 - 07/2005
2Kyphoplasty
06/2013 - 01/2008
2Transplantation
07/2005 - 01/2002
1Intravenous Administration
10/2018